James and William Macarthur gave the site for this church and from c.1845 a small brick Church stood here, built by Father Gould, and was part of Campbelltown Parish.The first Mass in the area was celebrated by Father Therry in Thomas Galvin's Cottage, Elderslie, in the early 1820's.
In February 1859 with 800 people in attendance, Bishop Polding laid the foundation stone for a more substantial building beside the smaller one. It was consecrated the following November.
From 1860 Camden had its own Catholic Parish with Father Jerome Keating as Parish Priest followed by Father John Ridney.
William Munro designed the Church and the builder was J.B. Elphinstone. The smaller Church became Mrs. James' home and schoolhouse. This was demolished in 1901 and a new school built on the site in the early eighties.
In later years it became apparent with the fast growth of the Macarthur area that a new church was needed. The new and larger church and presbytery were built in 1987.